23 февраля, 2023 
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Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.
From inside the subanalyses, sufferers whose people used condoms completely of the time were put into two categories based on their answers so you can issue “Performed their partner’s manhood actually touching the opening of your own pussy without good condom?” In the event that sufferers always answered “no” for each and every act out-of vaginal sex in seven-day months, they were coded because the which have got “zero vaginal contact rather than a great condom.” Analyses was performed as revealed above, which have five kinds of new frequency from condom play with (completely without having any vaginal contact without an excellent condom, 100 % which Sober dating service includes or an unknown volume out of genital contact as opposed to a good condom, and three organizations less than completely, as explained a lot more than).
Similarly, Cox proportional-threats models were used to choose risk circumstances toward recognition from event cervical squamous intraepithelial sores within the 7 weeks prior to certain Pap attempt (on the basis of a previous observance that almost all lesions can be found following event infection 23 ). A beneficial 51-big date lag before each head to are integrated as the 51 days was the brand new shortest observed interval between the go out a female basic got intercourse and time away from detection of an instance lesion from inside the this research. Studies getting such sufferers was censored after the basic detection out of an incident lesion.
Results
This new suggest (±SD) period of the brand new 82 victims during the registration try 19.3±0.eight ages. The new victims completed 709 visits. The latest imply pursue-upwards time was 33.9±eleven.8 days, the newest suggest amount of check outs for every single lady is actually 8.6±dos.9, while the average time taken between visits try 4.step one weeks. Diary study was indeed ninety.eight percent complete, and condom research was indeed registered toward 99.step 3 percent regarding weeks that intercourse is claimed.
Desk 2
The fresh a dozen-day collective chance away from a primary HPV problems immediately following earliest intercourse is actually 37.dos percent (95 percent depend on interval, twenty-seven.2 in order to 44.4 percent). A maximum of 126 experience type of-specific attacks have been identified from inside the 40 female once they first got gender ( Table dos ). Incident infections was understood within the three people prior to it stated that have gender for the first time, together with one confident to own HPV types of 51, you to to own HPV sort of 6, and something to possess HPV versions forty, 61, and you will 66. The latest twenty-four-few days collective occurrence from cervical squamous intraepithelial lesions is actually fifteen.0 % (95 per cent rely on period, 8.step 3 so you’re able to 26.2 percent).